THERADAPTIVE: shaping the future of regenerative medicine at military treatment facilities
The Geneva Foundation
released a case study highlighting their work with FITCI member, Theradaptive.
Theradaptive is shaping the future of regenerative medicine
with a new platform to deliver therapeutics that promote targeted native tissue
repair. Their lead therapeutic, AMP2, is applied to an orthopedic implant to
regenerate damaged bone, therefore significantly helping to speed up the injury
healing process. For service members with combat trauma this can mean the difference
between amputation and limb preservation.
Geneva, a 501(c)3 non-profit organization that advances
military medicine through innovative scientific research, exceptional program
management, and a dedication to U.S. service members and veterans, their
families, and the global community, set the foundation for the development of
this technology by fast-tracking the R&D development and regulatory
milestones. Geneva Program Manager Linzie Wagner said, “Partnering with Theradaptive
to accelerate their technology’s development to various platforms was an
important step for them. Geneva was able to leverage its expertise in DoD
advanced technology development and identify turnkey applications and
opportunities to thrust this product forward, bringing it one step further to
first in human and ultimately the Warfighter.”
The technology has demonstrated superiority over standard of
care in all preclinical studies conducted to date, including studies at the
Cleveland Clinic and Mayo Clinic, where scientists were able to correct a bone
defect about 5 centimeter (2 inch). In 2020, Theradaptive opened an R&D
facility in Frederick, Maryland, expanding capabilities in therapeutic
manufacturing, implant design, and additive manufacturing of medical implants.
The company is establishing cGMP manufacturing capabilities to produce
therapeutics able to enter clinical trials in late 2022.Theradaptive was also
able to leverage funds provided by DoD contracts to further preclinical
development. The company was the recipient of the 2018 and 2019 Maryland Stem
Cell Research Fund Commercialization Grant and was named a finalist for the
2018 First Coast Innovation Challenge. The company was also selected for
contract award under the Advanced Regenerative Manufacturing Institute (ARMI)
Theradaptive has developed a platform technology that
enables the conversion of therapeutic proteins into variants that bind to
implants very tightly, supporting healing in tissues like bone and cartilage in
extremities to avoid amputation. The technology can also be applied to any
recombinant protein, thus enabling long-term, localized therapeutics for cancer
treatment, vascular, dermal, or cartilage repair. Theradaptive received federal
phase II funding under the Defense Health Agency's Small Business Innovation
Initiative Research Program and has a partnership on two DoD contracts valued
at over $5.2M to develop next-generation 3D-printed regenerative spinal fusion
Theradaptive, Inc., is a privately held biotechnology
company focused on regenerative medicine technology, and on getting their
therapeutic platform into the clinic since 2017.
The Frederick Innovative Technology Center, Inc. (FITCI) is a business incubator and accelerator designed to cultivate entrepreneurship in Frederick, Maryland.
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U.S. DEPARTMENT OF COMMERCE ANNOUNCES 51 “BUILD TO SCALE” GRANTS TOTALING $47 MILLIONTO FUEL INNOVATION AND TECH-BASED ECONOMIC DEVELOPMENT
Contact: EDA Public Affairs Department, (202) 482-4085
October 5, 2022
WASHINGTON – Today, U.S. Secretary of Commerce Gina Raimondo announced that the Department’s Economic Development Administration (EDA) is awarding 51 “Build to Scale” grants – totaling $47 million – to organizations that support technology entrepreneurs, catalyze innovation and fuel economic growth.
EDA’s “Build to Scale” program provides annual grants that aim to accelerate technology entrepreneurship by increasing inclusive access to entrepreneurial support and startup capital. The 2022 awardees will leverage an additional $48 million in matching funds from a variety of private and public sector sources. These EDA investments support advanced manufacturing, bioscience, clean energy and blue economy clusters in regions throughout the United States.
"Strengthening technology ecosystems are a critical key to the Biden Administration's efforts to build a stronger America,” said Secretary of Commerce Gina Raimondo. “Innovation and entrepreneurship have long been keys to American success and will continue to strengthen our collective economic and national security, as well as individual prosperity and well-being.”
"EDA is proud to partner with this year's 'Build to Scale' grantees as they invest in entrepreneurs and create equitable access to capital in their communities," said Assistant Secretary of Commerce for Economic Development Alejandra Y. Castillo. "These projects will give the next generation of industry-leading companies a seminal boost that will result in job creation and private investment – potentially transforming a regional economy and creating economic opportunity beyond what we can foresee.”
The 2022 Build to Scale program was comprised of two competitions––the Venture Challenge and the Capital Challenge. The Venture Challenge supports programs that enable high-growth technology entrepreneurship and foster inclusive access to proven entrepreneurship support models. The Capital Challenge increases access to capital in communities where risk capital is in short supply by providing operational support for early-stage investment funds, networks, and training programs that focus on both traditional and hybrid equity-based financing.
About the U.S. Economic Development Administration (www.eda.gov)
The mission of the U.S. Economic Development Administration (EDA) is to lead the federal economic development agenda by promoting competitiveness and preparing the nation's regions for growth and success in the worldwide economy. An agency within the U.S. Department of Commerce, EDA invests in communities and supports regional collaboration in order to create jobs for U.S. workers, promote American innovation, and accelerate long-term sustainable economic growth.