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June 06, 2020
Fine Tuning the Fight: Biotech Startups Tackle the COVID 19 Challenge
Frederick,
Maryland - Snuggled into the Catoctin Mountains, Frederick, Maryland,
captures travel headlines as a destination for its “hipstoric” character, a blend of picturesque
architecture and artful vibes enfolded with rich colonial history and a growing
reputation as a foodie haven, but something else is happening here. As the
world shudders to a halt, trying to stop the deadly spread of COVID-19
infections as if it were an invasion of invisible zombies, Frederick’s biotech
startups rev up for the fight.
The town’s
location, home to frontline biomedical research at Fort Detrick and easily
accessible to major East Coast cities like DC and Baltimore, make it an enclave
for scientific enterprise. The Frederick Innovative Technology Center, Inc.,
also known as FITCI, presses that advantage. The organization is an incubator
and accelerator started with public/private support in 2004, nurturing more
than 150 fledgling companies throughout the years. Today, FITCI is recognized
as a premier resource for technology and bioscience entrepreneurs because of
its in-depth programming, industry-specific mentoring and resource array.
Like businesses across the board, start-ups here are acutely affected by social distancing requirements, especially in active labs, and the need to protect employees while navigating a swiftly changing economy. FITCI’s Strategic Growth and Advisory Board (SGAB), acts as a board of directors for client companies. Successful C-suite executives populate several specialized sessions, readily sharing insight on everything from crafting a corporate culture to hiring a team, through establishing best practices, honing an investors’ pitch or learning when to delegate. The groups’ most pressing issue these days is helping emerging entrepreneurs tame the chaos, turning challenges into opportunities – both to preserve the nascent roots of future industry and economic stability while making a meaningful contribution in the fight against COVID-19.
Here are the companies and their stories: #COVID-19 Startups Tackle
COVID-19 - https://www.fitci.org/COVIDPR.html
VIRINTEL,
LLC - VirIntel is a diagnostics startup founded in
April 2020 in response to the pandemic. The company is developing a serological
antibody test for COVID 19 that will tell whether a person was
infected with the coronavirus and has gained the immunity as well as will
help to evaluate what kind of immunity the person has now. The
company hopes that its test will show greater accuracy than current market
tests, which often suffer from higher-than-acceptable false
negativity/positivity. Learn more
VERALOX
Therapeutics - VERALOX
Therapeutics is a small-molecule biotech company formed in September 2017. The
company initially garnered attention for its first product, VLX-1005, a
promising rare blood disorder treatment drug for heparin-induced
thrombocytopenia and thrombosis (HITT).
With the unexpected danger in COVID-19 infections and increased risk of
pulmonary embolism (micro clots in the lungs) the VLX-1005 can be used to turn
the activation state of the platelets off. This does not kill platelets, but
does prevent them from forming clots. Currently, VERALOX is gathering
COVID-19 patient blood samples for testing. Once through GLP toxicology
testing, the drug poses promising use as an emergency therapy if a second wave
of COVID-19 infection occurs. Learn more
Integrated
BioTherapeutics, Inc. - Integrated BioTherapeutics (IBT) is a
biotechnology company focused on discovering novel vaccines and therapeutics
for emerging infectious diseases. Their two main pipelines are antiviral
(filoviruses) and antibacterial (novel vaccines and therapeutics against
bacterial infections). In addition, IBT has a CRO division providing discovery
services and reagents for pharma/Biotech and academic institutions. Service
including in-vitro screening (in-house models for testing whether the virus can
be neutralized) and in-vivo models (allows translation of the in-vitro
screening to an in-vivo model). Faced with an 80% dip in demand for research
tools for universities and industry, they’ve effectively pivoted to offering
services for COVID-19 research. Learn more
Velocidy Bio, Inc. - Velocidy Bio delivers solutions that
decrease time-to-results for global biological laboratories,
often condensing wait time from hours or days into minutes. Along
with the company’s Dutch biotech partner, Molecular
Biology Systems (MBS), they introduced NEXTGENPCR, a revolutionary new
method that decreases testing time for SARS-CoV-2 to eight minutes,
compared to current systems that take over an hour. The product has the potential to revolutionize testing
capabilities during the pandemic. It could potentially test
every employee at nearby Frederick Memorial Hospital every day in about 3
hours. Velocidy Bio is also
collaborating with FITCI graduate GM Biosciences on a COVID-19 testing
project. Learn more
Danuvius Biosciences - Established in 2020 as a
spin‐out of Bioworld Consulting Laboratories, Danuvius Biosciences develops
monoclonal antibodies for therapies and diagnostic assays for treatment and
diagnosis of multi-drug resistant bacterial infections. Because COVID-19
symptoms are very similar to flu, Danuvius Biosciences decided to adapt its
rapid (10 minutes) multiplex diagnostic assay to detect and identify the most
common infectious agents associated with respiratory infections. This rapid Point of Care multiplex assay will
be able to detect and identify the infectious agent in minutes in physician’s
office or hospitals, facilitating correct treatment of patients. Validations
for the other infectious agents are also in progress. Learn more
Hawkeye MedTech - Hawkeye
MedTech, Inc. created TotalCare, a unique telemedicine platform that lets
patients schedule virtual visits with their own healthcare providers. The
company started market validation as the COVID-19 crisis began unfolding. The platform lets patients get the care they
need from the comfort of their home or office, while adhering to the highest
principals of patient privacy and security. Learn more
RebuImmunity, LLC - RebuImmunity,
LLC is a small pharmaceutical entity developing recombinant chimeric proteins
for clinical drug research and development needs. The company’s
patent-pending human-source chimeric protein (BY-001) is a promising novel drug
aimed at treating patients with autoimmune diseases. In response
COVID-19, RebuImmunity proposed a chimeric protein (RADA2-Fc4) that contains
only the certain binding domain of a protein in ACE-2, but does not include
catalytic domain of angiotensin II, this structure prevents the protein from
interfering with circulating angiotensin II levels. The Fc4 part in this
chimeric protein can form a three-part structure, which is necessary for
2019-nCoV binding. Studies show that COVID-19 uses the receptor binding domain
(RBD) for its invading cells. In effect, this drug uses existing therapeutic
targets as a springboard for the treatment of COVID-19. Learn more
GoFightCOVID.com - The Edge graduate Gary Lopez helms Tiny Code, an emergency
communication device that facilitates essential communication during natural
disasters, but COVID-19 prompted him to start GoFightCovid, a free delivery
platform for those who are most at-risk for contracting the devastating virus. Learn more
CarrTech, LLC - Sue Carr is a graduate of FITCI’s first
intensive accelerator series, The Edge. A former pharmacist with 35+ years’
experience, Carr and her partners created a next-generation filtered needle for
safer, easier, quicker drug delivery with less medical waste. According to
Carr, it is a much-need update to the current, cumbersome 2-needle system which
can result in needle-stick and glass shard injuries. Learn more
Poochon
Scientific - Poochon Scientific provides mass spectrometry-based protein
analysis services and Sanger DNA sequencing services. CEO Jon Hao says he sees
a special responsibility to help fight COVID-19. The company helps biomedical
research institutions, biotechnology and pharmaceutical companies through DNA
sequencing and Proteomics solutions. Learn more
Molecular Tools, LLC - Dr. Olena Lar founded Molecular Tools in
2018 with the mission to translate scientific discoveries into easy-to-use
standardized tests for biomedical research and clinical diagnostics. Right
before the pandemic, Molecular Tools released their first product, an
Unconjugated Bilirubin Quantification Kit, designed for easy and direct
measurement of unconjugated bilirubin in biological specimens. When the global
health emergency put a halt on most research, Dr. Lar joined CianDx- diagnostic
lab in Frederick, MD, to support COVID-19 testing. Learn more
StepFusion Solutions
- The Tate Home Assistant is StepFusion’s first product line, now in
development. It is a series of everyday items with smart sensors to support dementia
care at home, in senior-living communities, and in dedicated nursing
facilities. The product can determine how the person is doing or feeling,
whether they are showing any COVID-19 symptoms. This information is reported to
family or care providers immediately, so they can take the appropriate actions. Learn more
Integrated Pharma Services, LLC
- Integrated
Pharma Services (IPS), is an award-winning Contract Research Organization (CRO)
started by Dr. Mina Izadjoo, the company’s president and Chief Science
Officer. IPS engages
Ph.D. level scientists and skilled technical staff to design, troubleshoot,
conduct, analyze, and report scientific data. Recently, IPS received $100K grant from the
State of Maryland for manufacturing much-needed surgical masks. IPS tests antiviral properties of new
products and devices, including essential personal protective equipment (PPE)
and is offering consulting and testing services for COVID diagnostic kits. Learn more
RoosterBio,
Inc. - RoosterBio has had a steep trajectory from
one-man show to international market disruptor. The company remains laser
focused on the rapid commercialization of scalable regenerative cures using
human mesenchymal stromal/stem cells (hMSC). RoosterBio’s products and
services – mesenchymal cells, bioprocess growth and EV collection media –
already changed how companies and institutions produce, consume and use living
cells, effectively eliminating the bottlenecks in stem cell accessibility. Exciting news, since clinical research suggests that hMSCs might be
helpful against the end stage of severe COVID-19, or acute respiratory distress
syndrome (ARDS), or to mitigate some of the damaging inflammatory
response. Founder Jon A. Rowley, PhD,
says that may give patients a fighting chance against severe COVID-19. Learn more
READ more details about each of these companies
at https://www.fitci.org/COVIDPR.html